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AOA (artificial oocyte activation):
AOA (artificial oocyte activation):
Fertilization problems are the major problems that may be faced in 30-55% of the patients during an intracytoplasmic sperm injection (ICSI) cycle. A successful oocyte activation depends on factors related to both sperm and oocyte, and one of the important factors that mediates the process is Ca2+ concentration within the oocyte. Artificial oocyte activation (AOA) is a method used for fertilization problems that commonly involve the usage of Ca2+ ionophores and is usually used in problems such as total fertilization failure (TFF) and globozoospermia.
Many chemical substances are known to induce an intracellular calcium surge and subsequently activate the oocytes, such as calcium ionophore, ethanol, ionomycin, puromycin, strontium chloride, probol ester and thimerosal. Several experiments have revealed that the artificial oocyte activation with calcium ionophore led to an increase in intracellular free calcium, mimicking physiologic mechanisms that cause oocyte activation. Therefore, this product was designed to facilitate the effect of artificial oocyte activation with different activation materials on fertilization, cleavage and pregnancy rate after ICSI in infertile men suffering from teratoospermia.
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Vials of 5 micron individually prepared for each case.
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